Maria Paola Costi Maria Paola Costi
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    • Protein-protein interaction in colorectal cancer
    • New Medicines for Trypanosomatidic infections
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  • Protein-protein interaction in colorectal cancer

Projects

Protein-protein interaction in colorectal cancer

1: Pozzi C, Lopresti L, Santucci M, Costi MP, Mangani S. Evidence of

Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced

by the Interface Mutation Q62R. Biomolecules. 2019 Apr 3;9(4). pii: E134. doi:

10.3390/biom9040134. PubMed PMID: 30987202; PubMed Central PMCID: PMC6523895.

 

2: Pozzi C, Ferrari S, Luciani R, Costi MP, Mangani S. Structural and Functional 

Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C,

New Perspectives for the Development of hTS Inhibitors. Molecules. 2019 Apr

7;24(7). pii: E1362. doi: 10.3390/molecules24071362. PubMed PMID: 30959951;

PubMed Central PMCID: PMC6479699.

 

3: Vanossi D, Caselli M, Pavesi G, Borsari C, Linciano P, Costi MP, Ponterini G. 

Excited-state intramolecular proton transfer in a bioactive flavonoid provides

fluorescence observables for recognizing its engagement with target proteins.

Photochem Photobiol Sci. 2019 Mar 22. doi: 10.1039/c9pp00026g. [Epub ahead of

print] PubMed PMID: 30900698.

 

4: Saxena P, Severi L, Santucci M, Taddia L, Ferrari S, Luciani R, Marverti G,

Marraccini C, Tondi D, Mor M, Scalvini L, Vitiello S, Losi L, Fonda S, Pacifico

S, Guerrini R, D'Arca D, Ponterini G, Costi MP. Conformational Propensity and

Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate

Synthase and Ovarian Cancer Cell Growth. J Med Chem. 2018 Aug

23;61(16):7374-7380. doi: 10.1021/acs.jmedchem.7b01699. Epub 2018 Aug 13. PubMed 

PMID: 30035541.

 

5: Severi L, Losi L, Fonda S, Taddia L, Gozzi G, Marverti G, Magni F, Chinello C,

Stella M, Sheouli J, Braicu EI, Genovese F, Lauriola A, Marraccini C, Gualandi A,

D'Arca D, Ferrari S, Costi MP. Proteomic and Bioinformatic Studies for the

Characterization of Response to Pemetrexed in Platinum Drug Resistant Ovarian

Cancer. Front Pharmacol. 2018 May 8;9:454. doi: 10.3389/fphar.2018.00454.

eCollection 2018. PubMed PMID: 29867465; PubMed Central PMCID: PMC5952181.

 

6: Rondanin R, Lettini G, Oliva P, Baruchello R, Costantini C, Trapella C, Simoni

D, Bernardi T, Sisinni L, Pietrafesa M, Ponterini G, Costi MP, Vignudelli T,

Luciani R, Matassa DS, Esposito F, Landriscina M. New TRAP1 and Hsp90 chaperone

inhibitors with cationic components: Preliminary studies on mitochondrial

targeting. Bioorg Med Chem Lett. 2018 Jul 15;28(13):2289-2293. doi:

10.1016/j.bmcl.2018.05.031. Epub 2018 May 15. PubMed PMID: 29807796.

 

7: Ferrari S, Severi L, Pozzi C, Quotadamo A, Ponterini G, Losi L, Marverti G,

Costi MP. Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth.

Vitam Horm. 2018;107:473-513. doi: 10.1016/bs.vh.2017.12.002. Epub 2018 Feb 12.

Review. PubMed PMID: 29544641.

 

8: Lettini G, Maddalena F, Sisinni L, Condelli V, Matassa DS, Costi MP, Simoni D,

Esposito F, Landriscina M. TRAP1: a viable therapeutic target for future cancer

treatments? Expert Opin Ther Targets. 2017 Aug;21(8):805-815. doi:

10.1080/14728222.2017.1349755. Epub 2017 Jul 18. Review. PubMed PMID: 28664757.

 

9: Sacchetti F, D'Arca D, Genovese F, Pacifico S, Maretti E, Hanuskova M,

Iannuccelli V, Costi MP, Leo E. Conveying a newly designed hydrophilic anti-human

thymidylate synthase peptide to cisplatin resistant cancer cells: are

pH-sensitive liposomes more effective than conventional ones? Drug Dev Ind Pharm.

2017 Mar;43(3):465-473. doi: 10.1080/03639045.2016.1262870. Epub 2016 Dec 26.

PubMed PMID: 27885848.

 

10: Siragusa L, Luciani R, Borsari C, Ferrari S, Costi MP, Cruciani G, Spyrakis

F. Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The

Thymidylate Synthase Case. ChemMedChem. 2016 Aug 5;11(15):1653-66. doi:

10.1002/cmdc.201600121. Epub 2016 Jul 12. PubMed PMID: 27404817.

 

11: Ponterini G, Martello A, Pavesi G, Lauriola A, Luciani R, Santucci M, Pelà M,

Gozzi G, Pacifico S, Guerrini R, Marverti G, Costi MP, D'Arca D. Intracellular

quantitative detection of human thymidylate synthase engagement with an

unconventional inhibitor using tetracysteine-diarsenical-probe technology. Sci

Rep. 2016 Jun 2;6:27198. doi: 10.1038/srep27198. PubMed PMID: 27250901; PubMed

Central PMCID: PMC4890114.

 

12: Taddia L, D'Arca D, Ferrari S, Marraccini C, Severi L, Ponterini G, Assaraf

YG, Marverti G, Costi MP. Inside the biochemical pathways of thymidylate synthase

perturbed by anticancer drugs: Novel strategies to overcome cancer

chemoresistance. Drug Resist Updat. 2015 Nov;23:20-54. doi:

10.1016/j.drup.2015.10.003. Epub 2015 Oct 31. Review. PubMed PMID: 26690339.

 

13: Sacchetti F, Marraccini C, D'Arca D, Pelà M, Pinetti D, Maretti E, Hanuskova 

M, Iannuccelli V, Costi MP, Leo E. Enhanced anti-hyperproliferative activity of

human thymidylate synthase inhibitor peptide by solid lipid nanoparticle

delivery. Colloids Surf B Biointerfaces. 2015 Dec 1;136:346-54. doi:

10.1016/j.colsurfb.2015.09.040. Epub 2015 Sep 25. PubMed PMID: 26433347.

 

14: Salo-Ahen OM, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani

S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC. Hotspots

in an obligate homodimeric anticancer target. Structural and functional effects

of interfacial mutations in human thymidylate synthase. J Med Chem. 2015 Apr

23;58(8):3572-81. doi: 10.1021/acs.jmedchem.5b00137. Epub 2015 Apr 1. PubMed

PMID: 25798950; PubMed Central PMCID: PMC4634673.

 

15: Santucci M, Vignudelli T, Ferrari S, Mor M, Scalvini L, Bolognesi ML, Uliassi

E, Costi MP. The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as

Targets for Regenerative Medicine and Cancer Treatment. J Med Chem. 2015 Jun

25;58(12):4857-73. doi: 10.1021/jm501615v. Epub 2015 Mar 11. Review. PubMed PMID:

25719868.

 

16: Tochowicz A, Santucci M, Saxena P, Guaitoli G, Trande M, Finer-Moore J,

Stroud RM, Costi MP. Alanine mutants of the interface residues of human

thymidylate synthase decode key features of the binding mode of allosteric

anticancer peptides. J Med Chem. 2015 Jan 22;58(2):1012-8. doi:

10.1021/jm5011176. Epub 2014 Dec 29. PubMed PMID: 25427005.

 

 

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